KETAMINE MAYO CLINIC OPTIONS

Metabolism Ketamine is metabolized by using N-dealkylation towards the Lively metabolite norketamine mainly by CYP2B6 and CYP3A4 and to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to variety hydroxynorketamine compounds by means of CYP-dependent pathways, which are conjugated with glucuronic aci